解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Many applications proposed for graphene require multiple sheets be assembled into a monolithic structure. The ability to maintain structural integrity upon large deformation is essential to ensure a macroscopic material which functions reliably. However, it has remained a great challenge to achieve high elasticity in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2251
更新日期:2012-01-01 00:00:00
abstract::Previous studies have demonstrated that aneuploidy in human embryos is surprisingly frequent with 50-80% of cleavage-stage human embryos carrying an abnormal chromosome number. Here we combine non-invasive time-lapse imaging with karyotypic reconstruction of all blastomeres in four-cell human embryos to address the hy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2249
更新日期:2012-01-01 00:00:00
abstract::A variety of flexible and stretchable electronics have been reported for use in flexible electronic devices or biomedical applications. The practical and wider application of such flexible electronics has been limited because commercial electronic components are difficult to be directly integrated into flexible stretc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1980
更新日期:2012-01-01 00:00:00
abstract::Real-time imaging of moving organs and tissues at microscopic resolutions represents a major challenge in studying the complex biology of live animals. Here we present a technique based on a novel stabilizer setup combined with a gating acquisition algorithm for the imaging of a beating murine heart at the single-cell...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2060
更新日期:2012-01-01 00:00:00
abstract::Protein integration into biological membranes is a vital cellular event for all organisms. We previously reported an integration factor in the inner membrane of Escherichia coli, named MPIase (membrane protein integrase). Here we show that in contrast to previously identified integration factors that are proteins, MPI...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2267
更新日期:2012-01-01 00:00:00
abstract::The development of stimulus-responsive polymeric materials is of great importance, especially for the development of remotely manipulated materials not in direct contact with an actuator. Here we design a photoresponsive supramolecular actuator by integrating host-guest interactions and photoswitching ability in a hyd...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2280
更新日期:2012-01-01 00:00:00
abstract::Device applications of graphene such as ultrafast transistors and photodetectors benefit from the combination of both high-quality p- and n-doped components prepared in a large-scale manner with spatial control and seamless connection. Here we develop a well-controlled chemical vapour deposition process for direct gro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2286
更新日期:2012-01-01 00:00:00
abstract::Daily-life foldable items, such as popup tents, the curved origami sculptures exhibited in the Museum of Modern Art of New York, overstrained bicycle wheels, released bilayered microrings and strained cyclic macromolecules, are made of rings buckled or folded in tridimensional saddle shapes. Surprisingly, despite thei...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2311
更新日期:2012-01-01 00:00:00
abstract::Nuclear factor-κB (NFκB) and peroxisome proliferator activated receptor-γ (PPARγ) are both transcription factors that perform distinct but overlapping roles in cellular regulation. Here we report that PPARγ acts as an E3 ubiquitin ligase, physically interacting with p65 to induce its ubiquitination and degradation. Th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2270
更新日期:2012-01-01 00:00:00
abstract::One-fourth of Plasmodium falciparum proteins have asparagine repeats that increase the propensity for aggregation, especially at elevated temperatures that occur routinely in malaria-infected patients. Here we report that a Plasmodium Asn repeat-containing protein (PFI1155w) formed aggregates in mammalian cells at feb...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2306
更新日期:2012-01-01 00:00:00
abstract::Carrier multiplication describes an interesting optical phenomenon in semiconductors whereby more than one electron-hole pair, or exciton, can be simultaneously generated upon absorption of a single high-energy photon. So far, it has been highly debated whether the carrier multiplication efficiency is enhanced in semi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2183
更新日期:2012-01-01 00:00:00
abstract::Heterostructured material systems devoid of ferroic components are presumed not to display ordering associated with ferroelectricity. In heterostructures composed of transition metal oxides, however, the disruption introduced by an interface can affect the balance of the competing interactions among electronic spins, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2061
更新日期:2012-01-01 00:00:00
abstract::Cellular events that occur across the seminiferous epithelium in the mammalian testis during spermatogenesis are tightly coordinated by biologically active peptides released from laminin chains. Laminin-γ3 domain IV is released at the apical ectoplasmic specialization during spermiation and mediates restructuring of t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2171
更新日期:2012-01-01 00:00:00
abstract::Theory, simulations and experimental results have suggested an important role of internal friction in the kinetics of protein folding. Recent experiments on spectrin domains provided the first evidence for a pronounced contribution of internal friction in proteins that fold on the millisecond timescale. However, it ha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2204
更新日期:2012-01-01 00:00:00
abstract::Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understandin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2112
更新日期:2012-01-01 00:00:00
abstract::Alterations in the methylation of promoters of cancer-related genes are promising biomarkers for the early detection of disease. Compared with single methylation alteration, assessing combined methylation alterations can provide higher association with specific cancer. Here we use cationic conjugated polymer-based flu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2209
更新日期:2012-01-01 00:00:00
abstract::Extracellular matrix interactions have essential roles in normal physiology and many pathological processes. Although the importance of extracellular matrix interactions in metastasis is well documented, systematic approaches to identify their roles in distinct stages of tumorigenesis have not been described. Here we ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2128
更新日期:2012-01-01 00:00:00
abstract::Many crystals, such as those of metals, can transform from one symmetry into another having lower free energy via a diffusionless transformation. Here we create binary colloidal crystals consisting of polymer microspheres, pulled together by DNA bridges, that induce specific, reversible attractions between two species...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2206
更新日期:2012-01-01 00:00:00
abstract::Current approaches to monitor and quantify cell division in live cells, and reliably distinguish between acytokinesis and endoreduplication, are limited and complicate determination of stem cell pool identities. Here we overcome these limitations by generating an in vivo reporter system using the scaffolding protein a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2089
更新日期:2012-01-01 00:00:00
abstract::Understanding the role of intermolecular interaction on through-space charge transfer characteristics in π-stacked molecular systems is central to the rational design of electronic materials. However, a quantitative study of charge transfer in such systems is often difficult because of poor control over molecular morp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2083
更新日期:2012-01-01 00:00:00
abstract::Memory consolidation requires a timely controlled interplay between the hippocampus, a brain region important for memory formation, and the cortex, a region recruited for memory storage. Here we show that memory consolidation is associated with specific epigenetic modifications on histone proteins that have a distinct...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1997
更新日期:2012-01-01 00:00:00
abstract::Hearing relies on mechanical stimulation of stereocilia bundles on the sensory cells of the inner ear. When sound hits the ear, each stereocilium pivots about a neck-like taper near their base. More than three decades of research have established that sideways deflection of stereocilia is essential for converting mech...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2100
更新日期:2012-01-01 00:00:00
abstract::Nanopatterning by molecular self-assembly has been a topic of intense research in pursuit of 'bottom-up' methods of generating structures for use in nanotechnology. The systems most widely studied have been two- and three-dimensional morphologies of block copolymers. However, T- and X-shaped polyphilic liquid crystals...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2096
更新日期:2012-01-01 00:00:00
abstract::Nanostructured silicon has generated a lot of interest in the past decades as a key material for silicon-based photonics. The low absorption coefficient makes silicon nanocrystals attractive as an active medium in waveguide structures, and their third-order nonlinear optical properties are crucial for the development ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2188
更新日期:2012-01-01 00:00:00
abstract::A non-syngas direct steam reforming route is investigated for the conversion of methanol to hydrogen and carbon dioxide over a CuZnGaO(x) catalyst at 150-200 °C. This route is in marked contrast with the conventional complex route involving steam reformation to syngas (CO/H2) at high temperature, followed by water gas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2242
更新日期:2012-01-01 00:00:00
abstract::Pupylation is a posttranslational protein modification occurring in mycobacteria and other actinobacteria that is functionally analogous to ubiquitination. Here we report the crystal structures of the modification enzymes involved in this pathway, the prokaryotic ubiquitin-like protein (Pup) ligase PafA and the depupy...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2009
更新日期:2012-01-01 00:00:00
abstract::The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2318
更新日期:2012-01-01 00:00:00
abstract::Architectural proteins have an important role in shaping the genome and act as global regulators of gene expression. How these proteins jointly modulate genome plasticity is largely unknown. In archaea, one of the most abundant proteins, Alba, is considered to have a key role in organizing the genome. Here we characte...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2330
更新日期:2012-01-01 00:00:00
abstract::The metazoan TREX complex is recruited to mRNA during nuclear RNA processing and functions in exporting mRNA to the cytoplasm. Nxf1 is an mRNA export receptor, which binds processed mRNA and transports it through the nuclear pore complex. At present, the relationship between TREX and Nxf1 is not understood. Here we sh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2005
更新日期:2012-01-01 00:00:00
abstract::A collective order of spin and charge degrees of freedom into stripes has been predicted to be a possible ground state of hole-doped CuO(2) planes, which are the building blocks of high-temperature superconductors. In fact, stripe-like spin and charge order has been observed in various layered cuprate systems. For the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2019
更新日期:2012-01-01 00:00:00
abstract::Self-assembly of small molecules in water to form nanofibres, besides generating sophisticated biomaterials, promises a simple system inside cells for regulating cellular processes. But lack of a convenient approach for studying the self-assembly of small molecules inside cells hinders the development of such systems....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2040
更新日期:2012-01-01 00:00:00
abstract::An essential issue in the development of materials presenting an accurately functionalized surface is to achieve control of layer structuring. Whereas the very popular method based on the spontaneous adsorption of alkanethiols on metal faces stability problems, the reductive electrografting of aryldiazonium salts yiel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2121
更新日期:2012-01-01 00:00:00
abstract::The worldwide biodiversity crisis has intensified the need to better understand how biodiversity and human disturbance are related. The 'intermediate disturbance hypothesis' suggests that disturbance regimes generate predictable non-linear patterns in species richness. Evidence often contradicts intermediate disturban...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2145
更新日期:2012-01-01 00:00:00
abstract::The study of carrier multiplication has become an essential part of many-body physics and materials science as this multiplication directly affects nonlinear transport phenomena, and has a key role in designing efficient solar cells and electroluminescent emitters and highly sensitive photon detectors. Here we show th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1598
更新日期:2011-12-20 00:00:00
abstract::The interband cascade laser differs from any other class of semiconductor laser, conventional or cascaded, in that most of the carriers producing population inversion are generated internally, at semimetallic interfaces within each stage of the active region. Here we present simulations demonstrating that all previous...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1595
更新日期:2011-12-13 00:00:00
abstract::Chirality and liquid crystals are both widely expressed in nature and biology. Helical assembly of mesophasic molecules and colloids may produce intriguing chiral liquid crystals. To date, chiral liquid crystals of 2D colloids have not been explored. As a typical 2D colloid, graphene is now receiving unprecedented att...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1583
更新日期:2011-12-06 00:00:00
abstract::A long-standing and profound problem in astronomy is the difficulty in obtaining deep near-infrared observations due to the extreme brightness and variability of the night sky at these wavelengths. A solution to this problem is crucial if we are to obtain the deepest possible observations of the early Universe, as red...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1584
更新日期:2011-12-06 00:00:00
abstract::Osteoderms are bones embedded within the dermis, and are common to select members of most major tetrapod lineages. The largest known animals that bear osteoderms are members of Titanosauria, a diverse clade of sauropod dinosaurs. Here we report on two titanosaur osteoderms recovered from the Upper Cretaceous Maevarano...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1578
更新日期:2011-11-29 00:00:00
abstract::Multi-partite entangled states are important for developing studies of quantum networking and quantum computation. To date, the largest number of particles that have been successfully manipulated is 14 trapped ions. Yet in quantum information science, photons have partic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1556
更新日期:2011-11-22 00:00:00
abstract::Artificial molecules containing just one or two electrons provide a powerful platform for studies of orbital and spin quantum dynamics in nanoscale devices. A well-known example of these dynamics is tunnelling of electrons between two coupled quantum dots triggered by mi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1561
更新日期:2011-11-22 00:00:00